Drug discovery and screening
Our purpose is to predicting and screening the early physicochemical properties, biological activities, ADME properties and toxicity of candidate compounds. It could improve research efficiency, reduce research risk, and guide drug chemists in rational structural optimization. We can also provide computer-assisted screening, cell-based screening and in vivo screening.
Service items
1.Computer aided screening
Hit screening in silicon
Molecular docking
Physical and chemical properties prediction
Metabolic properties prediction
Toxicity prediction
2.In vitro screening
Cell-based screening (tumor, diabetes, immunity, etc.)
High-content screening
Cytotoxicity screening（MTT、CCK-8）
Genotoxicity screening（AMES, Micronucleus assay, Chromosomal aberration test, SCGE/ comet assay）
Target organ toxicity screening(HTS)
Binding rate of plasma protein, BRPP
Cell permeability test
Metabolic stability test(Liver microsome, S9, Hepatocyte, plasma)
Metabolite identification
3.In vivo screening
Pharmacodynamic screening( tumour, bleeding and coagulation, metabolic disease, cardiovascular disease, neurological and psychiatric disease, etc.)
Single dose and cumulative toxicity screening
in vivo PK
The guidelines to be followed
Refer to the OECD related in vitro test guidelines and test methods in the literature
Qualification platform
National Shenyang Center for New Drug Safety Evaluation and Research
Key Laboratory of New Drug Safety Evaluation Technology of Liaoning Province
Biomedical Safety Evaluation Sub-platform of Liaoning Province
Equipments
Cell high content screening system, flow cytometry, multi-function microplate reader, gene chip scanner, real-time quantitative PCR, chemiluminescence imager, LC-MS/MS, etc.
Business Consulting
Ms.Li +86 024-85869185/ 18540366476