毒性篩選
綠色新化學(xué)品研發(fā)，需要早期毒性鑒定，預(yù)防發(fā)生風(fēng)險(xiǎn)?，F(xiàn)有化學(xué)品評(píng)估要求快速進(jìn)行毒性預(yù)測(cè)，以減少動(dòng)物的使用，使用新技術(shù)提高評(píng)價(jià)的準(zhǔn)確性，克服傳統(tǒng)方法周期長(zhǎng)和外推的不確定性。機(jī)構(gòu)基于計(jì)算機(jī)輔助篩選、體外細(xì)胞篩選及體內(nèi)動(dòng)物篩選實(shí)驗(yàn)體系，建立分級(jí)篩選策略，對(duì)化合物和生物小分子的理化性質(zhì)、ADME性質(zhì)、毒理學(xué)和環(huán)境效應(yīng)進(jìn)行預(yù)測(cè)和篩選。通過(guò)CMR\EDC\PBT等危害終點(diǎn)預(yù)測(cè)，能夠?qū)ξ镔|(zhì)毒性快速分級(jí)。結(jié)合計(jì)算模型暴露風(fēng)險(xiǎn)評(píng)估，為建立高危優(yōu)先管理物質(zhì)服務(wù)。
service items
1. In silicon Prediction
The self-built data platform and the public standard database were used to query the similarity compounds, and the QSAR method and the validation model were used to quickly predict the chemical, toxic and metabolic characteristics of the compounds. The service contents are as follows:
• Database virtual screening
• Physicochemical prediction
• Metabolic prediction
• Health impact prediction
• Environmental effect prediction
2. In Vitro Screening
Through high-throughput screening platform, cell culture and molecular biology methods were applied to rapidly screen the toxicity of compounds. The mechanism of drug discovery toxicity was studied to determine the critical path of toxicity. The content of the service is as follows:
• High content cell effect screening
• High throughput cytotoxicity screening
• Acute toxicity and genotoxicity
• Reproductive toxicity and EDC screening
• Target organ toxicity screening
3. In Vivo Screening
Model organisms such as rodents, zebrafish and transgenic organisms were used to screen compounds for toxicity. In vivo screening is to further verify the results of computer prediction and cell screening, to exclude the false positive results of screening, and to provide a reference for the pre-test of registered GLP test. The model creatures used are as follows:
• Acute rodent toxicity
• Aquatic toxicity screening
• Model animal toxicity screening
• Toxicity mechanism study
Application Field
研發(fā)階段通過(guò)安全性篩選，做出初步風(fēng)險(xiǎn)預(yù)測(cè)，幫助企業(yè)作出風(fēng)險(xiǎn)決策。通過(guò)QSAR和交叉讀數(shù)為化學(xué)品登記評(píng)估服務(wù)。依靠計(jì)算機(jī)預(yù)測(cè)、細(xì)胞培養(yǎng)方法和高通量篩選平臺(tái)，鑒定毒性關(guān)鍵事件，建立MOA和AOP路徑，對(duì)物質(zhì)風(fēng)險(xiǎn)作出準(zhǔn)確評(píng)估。
計(jì)算機(jī)風(fēng)險(xiǎn)預(yù)測(cè)
毒性機(jī)制MOA鑒定
AOP有害作用結(jié)局建立
Contact Us
Mr.Xing +86 024-62353435/ 18540366435
Ms.Li +86 024-85869185/ 18540366476